For assistance with an R grant, or to submit a sample R, contact the CCTS Research Commons (
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NIH
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Overview
The R01 is NIH’s most commonly used grant program. It supports discrete, specified, circumscribed research projects, is generally awarded for 3-5 years, and is supported by all Institutes and Centers at the NIH.
Other grant mechanisms in the R series are targeted to smaller, more specific aims, such as pilot studies, scientific meetings, clinical trial planning, small business innovation/technology transfer, and short-term projects.
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Eligibility
Research Grant Mechanisms | NIH
Early Stage Investigators (ESI) | NIH
New Investigators | NIH-NIAID - Types of NIH R Grants
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NIH Examples
NIH R Grant Examples from the CCTS
NIH R examples: Behavioral ResearchNIH R examples: Cancer Epidemiology
NIH R examples: Implementation Science
NIH R examples: Allergy and Infectious Diseases
NIH RePORTER – Research Grants | NIHDon't see an example that fits your needs?
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NIH Grant R Series Samples
R21-IHD-FY20-SABBAJR21-NINDS-FY16-SHACKA-FUNDED
R21-NINDS-FY16-SHACKA-UNFUNDED
Don't see an example that fits your needs? Contact the CCTS and we'll be happy to help!
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Specific Grant Components - Examples & Tips
Specific Aims:
Anatomy of a Specific Aims Page | BioScience Writers
Introduction to the Specific Aims Page | NIH NLM (PMC6133727)
Biosketch:
NIH Biosketch Form, Instructions & Example | NIHResearch Strategy:
Prepare Your Application | NIH NIAID
Other Sections:
Data Sharing Plan Samples | NIH NIAID
Key Elements to Consider in Preparing a Data Sharing Plan | NIH OER
Human Subjects Section
Vertebrate Animal Sections
Facilities & Resources
Data Management and Sharing
Authentication of Key Biologic a/o Chemical Resources
Other Tips:
Rigor, Reproducibility & Transparency (R2T) | CCTS
Rigor & Reproducibility | NIH - Additional Guidance and Instructions
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CCTS Resources
The CCTS offers resources to support research program development via multiple mediums whose focus may be specific to broad. Below is a select list of CCTS resources that can help faciliate your grant writing.
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Overview
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Other Sponsors
- National Science Foundation (NSF)
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Patient-Centered Outcomes Research Institute (PCORI)
PCORI Funded Portfolio | PCORI
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Agency for Healthcare Research and Quality's (AHRQ)
AHRQ Funded Portfolio | AHRQ
- Congressionally Directed Medical Research Programs (CDMRP)
- American Heart Association (AHA)
- CCTS Resources
These grant mechanisms establish discipline-aligned programs to provide institutional research training and mentored career development opportunities for trainees at the undergraduate, graduate, and postdoctoral levels as well as early career scholars (faculty).
To learn more about the T series, visit the NIH Institutional Training Grants page. For assistance with a T grant, or to submit a sample T, contact the CCTS
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NIH
- Eligibility & Types of Grants Available
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Examples of Successful Applications
The CCTS has partnered with successfully funded investigators from across its partner network to develop this compendium of best practice grant writing samples. Our goal is to share the wisdom of their award-winning experiences in communicating about research in support of both scientific excellence and discovery. We encourage you to emulate these fine examples, but please remain mindful of the difference between imitation and plagiarism. For more information, see: https://www.uab.edu/ethicsforauthors/
NIH RePORTER – T32 | NIH
Don't see an example that fits your needs?This email address is being protected from spambots. You need JavaScript enabled to view it. and we'll be happy to help! - Specific Grant Components
- Training Plans
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Other Guidance
Data Sharing Plan Samples | NIH NIAID
Key Elements to Consider in Preparing a Data Sharing Plan | NIH OER
SF 424 (R&R) Forms Instructions | NIH
Revise and Resubmit Tips | NIH NIAID
PHS Human Subjects and Clinical Trials Information Form Walk-through (video, 6 min.)
New Resources for Implementing the NIH Policy for Data Management and Sharing - CCTS Resources
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Federal Grant T Series Samples
The Ruth L. Kirschstein Institutional National Research Service Awards (NRSAs) support the training of biomedical, behavioral, and clinical researchers through institutional research training grants. The goal is to prepare qualified predoctoral and/or postdoctoral trainees for careers that have a significant impact on the health-related research needs of the Nation.
The T32 enables institutions to award NRSAs to Individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. The key for the sample documents provided for the T series is provided below.
Program Name Program Director Institute or Agency Award Trainee Type Interdisciplinary Training in Pathobiology and Rehabilitation Marcas Bamman NICHD New pre/post Training Program in Tumor Biology Etty Benveniste NINDS Competing Renewal pre/post Health Services and Outcomes Research Training Kenneth Saag AHRQ Competing Renewal pre/post Immunological Diseases and Basic Immunology Harry Schroeder NIAID Competing Renewal pre/post Translational and Molecular Sciences Rakesh Patel NIGMS New pre Rheumatic and Musculoskeletal Diseases Research Louis Bridges NIAMS New pre/post NIH
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Other Federal (NSF, AHRQ, PCORI)
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Eligibility, Grants Available, Examples, Guidance - National Science Foundation (NSF)
Eligibility & types of grants available:
https://www.grants.gov/web/grants/applicants/applicant-eligibility.html
Eligibility:
https://www.nsf.gov/eng/iip/pfi/eligibility.jsp
Examples of grants:
The CCTS has partnered with successfully funded investigators from across its partner network to develop this compendium of best practice grant writing samples. Our goal is to share the wisdom of their award-winning experiences in communicating about research in support of both scientific excellence and discovery. We encourage you to emulate these fine examples, but please remain mindful of the difference between imitation and plagiarism. For more information, see: https://www.uab.edu/ethicsforauthors/
Examples from University of South Florida
Specific Grant Components - Examples & Tips:
Approved Formats for the Biographical Sketch
Prepare & Submit Proposals
Training in Responsible Conduct of Research:
Additional Guidance and Instructions:
Introduction to Transformative Research | NSF
Proposal & Award Policies and Procedures Guide
Funding Opportunities
Due dates
About Funding
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Eligibility, Grants Available, Examples of Successful Applications, Guidance - Agency for Healthcare Research and Quality (AHRQ)
Eligibility & types of grants:
https://www.ahrq.gov/funding/training-grants/r36.html
https://www.ahrq.gov/cpi/about/profile/index.html
AHRQ National Research Service Award (NRSA) Program: AHRQ provides support for predoctoral and postdoctoral research education of scholars through the National Research Service Award (NRSA) grant program. These grants are administered through institutional and individual funding mechanisms.
https://www.ahrq.gov/funding/training-grants/nrsa.html
https://www.ahrq.gov/funding/training-grants/index.html
Additional Guidance and Instructions
Grants Process and Application Basics:
Application Submission Dates
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Eligibility, Grants Available, Examples, Guidance - Patient-Centered Outcomes Research Institute (PCORI)
Patient-Centered Outcomes Research Institute (PCORI):
Eligibility & types of grant available::
Health Conditions and Related Topics PCORI Funded Projects Address
Additional Guidance and Instructions:
Funding Opportunities
Funding application guidelines
Don't see an example that fits your needs?This email address is being protected from spambots. You need JavaScript enabled to view it. and we'll be happy to help! - CCTS Resources
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Eligibility, Grants Available, Examples, Guidance - National Science Foundation (NSF)
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Foundation, Private, Non-Profits
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Types of Grants Available
There are a large number of nonprofit organizations and for-profit businesses that also provide grants or other types of funding assistance.
Doris Duke Charitable Foundation
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Eligiblity, Examples, Guidance - Doris Duke Foundation
The CCTS has partnered with successfully funded investigators from across its partner network to develop this compendium of best practice grant writing samples. Our goal is to share the wisdom of their award-winning experiences in communicating about research in support of both scientific excellence and discovery. We encourage you to emulate these fine examples, but please remain mindful of the difference between imitation and plagiarism. For more information, see: https://www.uab.edu/ethicsforauthors/
Additional Guidance and Instructions
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Eligibility, Examples, Guidance - Burroughs Wellcome Fund
Eligibility & types of grant available
The majority of the BWF’s grantmaking is through competitive award programs. Most awards are made to degree-granting institutions in the United States and Canada on behalf of individual researchers, who must be nominated by their institution. All institutions receiving awards must be tax-exempt 501(c)(3) organizations.
Funding Opportunities
https://www.bwfund.org/funding-opportunities/ - CCTS Resources
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Types of Grants Available
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What is translational science?
- A field of investigation focused on understanding the scientific and operational principles underlying each step of the translational process
- A key tenant of translational science is understanding common causes of inefficiency and failure in translational research projects
- Application of scientific and operational innovation and strategies to improve the efficiency and effectiveness of all research
- Examples of translational barriers may be found on the CCTS Pilot Program website. Examples in the context of pilot projects may be found on the Translational Science in Pilots website.
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Are you seeking to better understand regulatory approvals and Just-in-Time requests?
- Who can help with Human Subject Research training, ethics (IRB) review and related regulatory requirements?
- CCTS Partner Institutions’ human subject research offices provide necessary training and review human subject research protocols to assure ethical conduct of research.
- UAB’s Office of the IRB
- Tuskegee University’s Human Participants Committee
- Auburn’s Office of Human Research
- University of Alabama at Tuscaloosa’s Institutional Review Board
- University of South Alabama’s Research Compliance and Assurance
- University of Mississippi’s Institutional Review Board
- Louisiana State University Health Science Center New Orleans’ Institutional Review Board
- Pennington Biomedical Research Campus’ Human Research Protection Program
- Tulane University’s Human Research Protection Office and IRBs
- Some Departments have Regulatory specialists as an administrative resource
- The CCTS Clinical Regulatory Support Program may be leveraged to assist investigators with regulatory questions or needs.
- CCTS Partner Institutions’ human subject research offices provide necessary training and review human subject research protocols to assure ethical conduct of research.
- What are NIH-defined clinical trials?
- The NIH’s definition of a clinical trial is a research study where one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes. The NIH provides additional information and a decision tool to help determine if a study meets the definition.
- Will I need to register my study in ClinicalTrials.gov?
- If your study meets the definition of an NIH-defined clinical trial, the study must be registered in ClinicalTrials.gov and results reported accordingly.
- Note: If the study is an NIH-defined clinical trial, many institutions require investigators to submit to ClinicalTrials.gov before submitting a human subjects research protocol or before IRB approval will be granted.
- What are Investigational New Drug or Biologic (IND) and Investigational Device Exemptions (IDE) submissions?
- The Regulatory Guidance for Academic Research of Drugs and Devices (ReGARDD) website provides an excellent overview of IND and IDE submissions.
- UAB’s Office of Research provides details about IND and IDE submissions
- Who can help with Vertebrate Animal training and regulatory requirements?
- UAB’s Institutional Animal Care and Use Committee
- Tuskegee University’s Institutional Animal Care and Use Committee
- Auburn University’s Institutional Animal Care and Use Committee
- University of Alabama at Tuscaloosa’s Institutional Animal Care and Use Committee
- University of South Alabama’s Institutional Animal Care and Use Committee
- University of Mississippi’s Institutional Animal Care and Use Committee
- Louisiana State University Health Science Center New Orleans’ Institutional Animal Care and Use Committee
- Tulane University’s Institutional Animal Care and Use Committee
- Where can I learn more about this program’s Just-in-Time Request?
- Applicants receiving a Notice of Selection are asked to provide Just-in-Time information. Investigators are asked to provide relevant regulatory approval(s), related documents and programmatic information using a dynamic Just-in-Time Request form. *This example is hosted by a development instance of the live version. Users are not able to “Submit” this form. Data entered will not/cannot be saved.
- Who can help with Human Subject Research training, ethics (IRB) review and related regulatory requirements?
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Additional Resources
- Tips on writing a research proposal
- Address the Top 10 Problems Reviewers Cite in Applications
- 23 Questions to Guide the Writing of a Quantitative Medical Education Research Proposal
- Top ten strategies to enhance grant-writing success
- Verify the novelty of your idea by searching publications (PubMed, dimensions.ai), awarded grants (NIH RePORTER, dimensions.ai, PIVOT) and registered trials (clinicaltrials.gov)
- Read awarded grants in the CCTS Grant Library (spoiler alert: these are NOT pilot proposals)
- Tips on writing a research proposal
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Examples of Translational Science in Pilots
The CCTS provides examples that may help you identify and/or frame your proposed work as translational science
How does it work?
TIES GOAL: To explore interdisciplinary scientific connections related to a clinical or experimental observation.
TIES APPROACH: This 1-hour venue invites a tailored group of investigators with complementary “disciplinary” expertise, often bridging the translational spectrum, to explore a clinical phenomenon in a more tractable system (bedside to bench) or an experimental insight in an advanced model (bench to bedside). TIES is also amenable for considering how to leverage scientific strategies in one discipline and applying them in another.
TIES FORMAT: the panel is tailored to the request in both time & expertise and aims to foster “productive collisions” that may lead to collaboration. The open conversation would ideally, though not necessarily, point to products (manuscripts, extramural applications, etc.) as an incentive.
What to prepare:
- Click here to sign up!
- Provide a succinct overview that describes (1) the scientific observation (a few sentences), (2) what expertise is sought
- Provide availability (days/times for conversation in the proximate 2 weeks)
- Indicate individuals you wish to attend (or not)
Optimal Timeline:
TIES panels lend to nascent ideas discussed in a setting that nurtures curiosity in the absence of constraint (grant deadline or demand of some product).How does it work?
iPanel GOAL: To discuss a scientific discovery, technology development or novel process that may have potential health application and/or commercialization.
iPanel APPROACH: A group of individuals with expertise in science, tech transfer and business development are brought together to help innovators chart a path forward. This 1-hour panel can be useful for those looking to further develop intellectual property, to submit a SBIR/STTR, to create a company or to disseminate non-patentable, evidence-based system interventions.
How to prepare:
- Click here to sign up!
- A CCTS Research Commons Liaison will contact you to discuss your project.
- Share a brief description of your technology, innovation, scientific discovery, etc.*
- Describe what expertise is sought and/or indicate individuals you wish to attend (or not)
- Provide availability (days/times for conversation in the proximate 2 weeks)
Optimal Timeline:
- Proposal submission approximately 4-6 months
* The CCTS has established a consortium-wide memorandum of understanding regarding scientific integrity and confidentiality. Participation in an iPanel does not qualify a discussant for inventor credit. Criteria for inventorship (a person who conceives the subject matter of at least one claim of an IP disclosure / patent) still apply.