Mechanisms of Memory. This course integrates the molecular, cellular, systems, and medical components of the core curriculum with an emphasis on cellular and molecular mechanisms underlying learning and memory. The course (1) synthesizes available information concerning the mechanisms of higher-order memory formation, (2) spans the range from learning theory to behavioral learning models, cellular physiology and biochemistry, (3) incorporates discussion on memory disorders, tying in these clinically important syndromes to synaptic plasticity and memory mechanisms; and (4) covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases.
Molecular Neurodegeneration. This advanced course covers several of the most important molecules involved in neurodegenerative disease, including Aβ, tau, apoE, TDP-43, α-synuclein, LRRK2, prion protein (PrP), and Huntingtin (HTT). The goal is to develop a deeper understanding of each protein’s normal structure/function and how these are altered in neurodegenerative disease by genetic changes or posttranslational modifications. Offered in Spring every other year, alternating with Translational Approaches in Neurodegeneration.Translational Approaches to Neurodegeneration. This course uses the field of neurodegeneration as a vehicle for conceptualizing the failures, current challenges, and successes of different translational approaches. This course emphasizes active learning principles by placing students into scenarios of direct relevance to a career in science (e.g., emulation of study section discourse, formal critical debate that happens at international symposia, and informal discussions between colleagues). Offered in Spring every other year, alternating with Molecular Neurodegeneration.
Clinical Evaluation of Cognitive Disorders. This course provides a hands-on interactive experience so that Ph.D. students experience first-hand the impact of neurological, psychiatric and neurodevelopmental disorders on brain function, and on the social fabric of the patient's life, their families and their community. The course has five “modules,” each composed of a one-hour classroom/didactic session, and a ½ day practicum component. The classroom sessions are held in consecutive weeks starting at the beginning of the semester. Most of the practicum sessions are individually scheduled, with each student visiting the various clinics for a one-on-one observership with a faculty mentor. The fMRI practicum is scheduled together as a group.