The Trial Innovation Network (TIN) is a platform for multi-center trials and studies that encompass a wide-range of disciplines. Investigators do not need to apply for a specific RFA, but should propose a multi-center trial or study. The Network will prioritize proposals for multi-center clinical trials and studies with patient-oriented endpoints with potential for impact on clinical practice and operational innovation as well as proposals that foster collaborations with other NIH ICs over proposals seeking funding from NCATS.
The TIN established three Network Central IRBs (CIRBs): Johns Hopkins University School of Medicine, The University of Utah, and Vanderbilt University Medical Center. The Network CIRBs use the SMART IRB Reliance Agreement through the IRB Reliance Exchange (IREx; formally SMART IRB Exchange).
What Makes a Good Proposal for the Trial Innovation Network?
- An optimal submission includes:
- Principal Investigator willing to partner with the TIN through the life cycle of the project
- Opportunity to study an innovative operational approach to improve quality, efficacy, or cost of clinical research
- More than 60 days allotted for consultation prior to planned grant submission with substantial project development
- Includes a multi-center study design (3 or more institutions)
- Fosters broad collaboration within the CTSA Program and NIH Institutes and Centers
- Includes all populations affected by the health condition being studied
- Opportunity to provide academic evidence to improve clinical trial designs, conduct, and reportability