Do you struggle with anxiety, depression, or feel that your quality of life has suffered due to your HIV diagnosis?

Researchers in the Department of Psychology at The University of Alabama at Birmingham are conducting a clinical trial of Acceptance and Commitment Therapy for the treatment of mental health concerns among men who have sex with men and are living with HIV.

Volunteers will attend 8 weekly roughly 1 hour sessions of psychotherapy delivered via HIPAA-compliant Zoom by a doctoral student in Medical/Clinical Psychology at University of Alabama at Birmingham. Participants will receive $10 upon completion of initial intake session and an additional $15 upon completion of final therapy session. To participate, you must be an active patient of UAB's 1917 clinic.

Complete this online screener to indicate interest: https://uab.co1.qualtrics.com/jfe/form/SV_8H8oWPLXTK532DQ

Reach out to uabACThivtrial@gmail.com with any questions!

KETO-WEI study in individuals with obesity:

The UAB Department of Nutrition Sciences is conducting a nutrition study looking at whether a ketogenic diet can benefit appetite, while increasing energy expenditure, during weight-loss maintenance in individuals with obesity who have recently lost weight.

You may qualify if you are between the ages of 18-65, have obesity, have NOT been diagnosed with Diabetes, are NOT pregnant, are willing to consume meal replacements during the weight loss phase (4-6 weeks) and a prescribed diet during the weight maintenance phase (6 weeks), and are willing to travel to UAB for testing visits.

Qualified participants will receive free meal replacements, food/meals, personal health information, individual sessions with a Registered Dietitian, and monetary compensation for their time.

For more information and to see if you qualify, please call 205-934-7119 or email catia197@uab.edu.

We are unlocking new gateways to treating depression and we are looking for volunteers to participate in a clinical trial.

Who's eligible for the study?

If you have been diagnosed with depression.
If you are between the ages of 18-64
If you are currently experiencing a major depressive episode that has lasted at least 3 weeks but not longer than 18 months.

If you are otherwise healthy and have not been diagnosed with other medically important conditions or psychiatric conditions such as bipolar disorder (BP), antisocial personality disorder (ASPD), obsessive compulsive disorder (OCD), borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD) or major diseases, have not had electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), deep brain stimulation or repetitive transcranial magnetic stimulation (TMS) within 5 years or have failed to respond to ECT at any time, This STUDY Might Be For You!

For more information, contact Dana Green at danagreen@uabmc.edu or 205-975-6426.

Join a clinical research study that seeks to improve the lives of those suffering from depression. We are looking for volunteers to participate in a clinical trial.

Are you eligible to enroll in the Amplify Study?

• Must be between 18 and 65 years of age and meet the DSM-5 criteria for a diagnosis of MDD.
• You are experiencing a moderate or severe major depressive episode of up to 12 months.
• You have been using a SSRI or SNRI antidepressant for at least 6 weeks and are having an inadequate response.
• You do not have a history of obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), panic disorder, or eating disorder, according to DSM-5 criteria.

For more information, contact Dana Green at (205) 975-6426 or danagreen@uabmc.edu or Candace Green at (205) 975-0068 or candacegreen@uabmc.edu.

You may be eligible to participate in a research study looking at the effects of sacubitril/valsartan on how your body handles sugar. This medication is related to blood pressure and is safe to take with or without hypertension. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart disease or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples.

Participants will be compensated $675 for completing all the visits.

To participate, please contact Tiffany at 205-934-0534 or email us at nauticalstudy@uabmc.edu.

The purpose of this NIH-funded trial is to examine the effects of three different diabetes treatments to determine if they improve night-time blood sugars.

This trial involves:

• A screening visit that includes a blood draw, urine test and physical exam
• Treatment with Metformin, Insulin Glargine (long-acting insulin) or the experimental drug Dorzagliatin which is FDA-approved for research, for up to 8 weeks
• 2-4 inpatient visits/ including two overnight stays at the Clinical Research Unit at 15th floor of Jefferson Tower.
• All visits to be completed within a three-month period.

Study-related tests and procedures are provided free of charge. Participants will be compensated up to $2,500 for study completion. All participants must be diagnosed with type 2 DM and not be on any type of insulin therapy.

Please contact Alaaeldin Hodhod at ahodhod@uabmc.edu or 205-996-9984 or Chanel Mason at 205-934-1921 or cnmason@uabmc.edu.

Learn more about the CT-388-104 Study testing the safety and effectiveness of a selective GLP-1/GIP investigational drug for those living with overweight or obesity with type 2 diabetes.

You may be able to join the CT-388-104 Study if you:

• Are 18 through 75 years old
• Have a body mass index (BMI) of 25 or above
• Have been diagnosed with type 2 diabetes
• Have tried to lose weight once or more through diet and exercise but without success

There are other requirements for taking part in this study. The study team will go over these with you.

If you qualify to join, you may receive at no cost:

• The investigational drug or placebo
• Close medical care and follow-up throughout the study
• Lifestyle management counseling

Contact us to find out more about the CT-388-104 Study:

Alex Rolling, CRC, RD
alp0029@uab.edu
205-996-2689

We are conducting a research study to find out if a new contact lens can treat nearsightedness in children. 

You can be a part of this study if your child

• Is 8 to less than 13 years old
• Needs glasses or contact lenses to see well at far objects
• Is willing to wear contact lenses

The study includes 6 visits over a year, and your child will receive eye examinations, contact lenses, lens fitting, and lens prescription at no cost.

If eligible, you will be compensated $250 at the completion of the study for your time and participation.

For more information, contact Sindhu Gurrala at sgurral2@uab.edu or (205) 975-3881 or study principal investigator Dr. Safal Khanal at skhanal@uab.edu or (205) 934-4558.

Interested in being part of vision rehabilitation research for healthy older adults aged 50-59 to lay the foundation of using a new device?

Here is an overview of what our study will involve!

The purpose of this study?

• Calculate baseline data for Bioness Integrated Therapy System (BITS) and identify its clinical implications in treating visual impairments.
• Compare the baseline data of Bioness Integrated Therapy System (BITS) to Dynavision for visual scanning.

Who are we looking for?

• Healthy adults aged 50-59 without physical, visual, or cognitive impairment and with no history of seizures or balance problems.
• Adults who are able to walk without assistive devices and are English speakers.

What would you have to do in 60 minutes?

• Fill out a short survey for demographic data.
• Quick functional screening of upper extremities.
• Perform four tests on BITS.
• Perform four tests on Dynavision.

Participants will receive a $25 gift card.

To participate in the study, please fill out this short survey:
https://uab.co1.qualtrics.com/jfe/form/SV_exEYGMKXxc230p0

For more information, please contact us at almulhim@uab.edu

The UAB Sexual Health Research Clinic is recruiting women ages 18 to 45 to assess the safety, tolerability, and efficacy of a new vaginal suppository in women diagnosed with bacterial vaginosis (BV). Eligible participants will be compensated for each completed visit.

• Are 18–45 years of age?
• Are you pre-menopausal?
• Have you been on birth control for the last 3 months and plan to continue use?
• Are you currently having any vaginal symptoms?
• Are you willing to abstain from sexual intercourse for at least one month?

Interested? Contact 205-934-8166 for more information.

Do you want to make a difference for kids? More children are at risk for type 2 diabetes, and you can help us learn why.

Type 2 diabetes is diagnosed when the body has problems with high blood sugar levels. This can lead to serious health problems if not identified and treated early.

DISCOVERY is a study for children 9-14 years old who may be at higher risk of developing type 2 diabetes.

What will happen in the study?

• In person and phone visits
• Lab tests
• Questionnaires
• Physical exams
• Glucose (blood sugar) monitors

Join families across the US to help us make a difference for all children and young people! This study does not involve medications and there is no cost to you. You will be compensated for your time in this study.

Contact us for more information:
205-517-1351
Discovery@uab.edu

Participants between the ages of 35 and 65 are needed for this study. The purpose of the study is to fill in what we don’t know about how schizophrenia affects people as they get older. We want to find out what we can do to help older individuals with schizophrenia live better lives. The study includes 4 visits over the course of two weeks. The screening visit will take 2 hours. The first study visit will take 3 hours. The second study visit will take 2 hours. The third study visit will take 9 hours. This study will include: a clinical interview, cognitive batteries, questionnaires and assessments related to your daily and psychiatric functioning, two 90 minute MRI scans of your brain, a fasting blood draw, and a urine drug screen and pregnancy test (for females). Compensation is up to $310. TO SEE IF YOU QUALIFY PLEASE CONTACT (205) 934-8203.

If you experience urine leakage and you are 65 years or older, you may qualify for the study.

We are assessing whether hip exercises can improve pelvic floor muscle strength and urinary leakage.

You will serve as a “control.” At the visit, you will undergo a routine examination (10 minutes) for urinary leakage and answer questionnaires (10-15 minutes).

You will come to clinic for two visits.

$100 ($50 at each visit) compensation will be provided.

For more information, please call 205.934.5498.

• Older than 40 years
• No Neurological Deficits
• No History of Psychotic Symptoms
• No diagnosis of a mood disorder
• No Diagnosis of HIV
• English Speaking

• Are you 18-60 years of age living with HIV, and want to be a part of a vaccine study?
• Is your viral load suppressed/undetectable?
• Are you able to receive a vaccine?
• Are you generally healthy?
• Are you willing to temporarily stop taking antiretrovirals?

You may qualify for a study looking at testing an experimental HIV vaccine with an experimental adjuvant to see how the immune responses change among participants who do an antiretroviral analytical treatment interruption (ATI) compared to those who do not. Compensation at each study visit will be provided for time and travel. Transportation services are also available upon request. If interested, please email sspaulding@uabmc.edu.

A Phase 3, Randomized, Multicenter, Open-label Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly Compared with Semaglutide Once Weekly in Adult Participants with Type 2 Diabetes and Inadequate Glycemic Control with Metformin with or without SGLT2 Inhibitor (TRANSCEND-T2D-2)

TRANSCEND-T2D-2 is a clinical research study for people with type 2 diabetes.
This study will test if an investigational medicine (the medicine being studied) can
help with blood glucose (sugar) and weight management compared with an existing
treatment for type 2 diabetes.

• Are aged 18 years or older
• Have type 2 diabetes
• Have been taking 1500mg or more of metformin each day for at least 3 months (with or without SGLT2i)
• Have a BMI of 25 or more
• Have HbA1c levels of 7.0% to 10.5%

• You must be 11 - 21 years old.
• You will be asked to walk, jump, step, and do exercises.
• Eligible participants will have multiple visits and can be compensated up to $430 depending on your tests.

We are looking for people with knee osteoarthritis to participate in a study to examine whether a diet intervention can reduce pain and improve quality of life. The commitment to this study will last approximately 7 weeks and include the following:

• Five (5) visits to UAB where you will fill out questionnaires, complete a DEXA scan, blood draw or Quantitative Sensory testing. These visits will last anywhere from 1-3 hrs.
• Six (6) weeks on a randomized diet where we will provide three (3) meals and two to three (2-3) snacks per day.

Participants must:

• Be currently suffering from pain related to knee osteoarthritis
• Be free from other serious health conditions (diabetes, cardiovascular disease, eating disorders, metabolic disease)

Participants will receive up to $250 for completing the study and meals will be provided. Please contact DIRECT at DIRECTPAIN1@gmail.com (205) 834-3628. Leave a short message with your name and number.

• 18-75 years old
• No diagnosis of any neurological disorders or psychiatric problems
• No history of problematic drug/alcohol use in the last 3 months

DAY or NIGHT, when is the best time to take your blood pressure medication?

Help us find out by joining our study at UAB by participating in the PRECISION-BP research study investigating the effects of Sacubitril/Valsartan or Valsartan on your body’s 24-hour rhythm of a hormone in your blood called natriuretic peptides. This hormone and the study medications are related to the heart. Eligible participants must be obese (BMI: 30-45 kg/m2) men and women, have high blood pressure, and have no history of heart or kidney problems. The study involves wearing a blood pressure monitor for 24 hours, 24-hour inpatient visits at UAB Hospital, taking medications, and collecting blood and urine samples. Meals will be provided at no cost. Participants will be compensated $575 for completing the study visits. Please e-mail Haley at PRECISION-BPSTUDY@uabmc.edu or call us at 205-975-5825 if you are interested.

Help us find out by joining our study at UAB by participating in the PRECISION-BP research study investigating the effects of Sacubitril/Valsartan or Valsartan on your body’s 24-hour rhythm of a hormone in your blood called natriuretic peptides. This hormone and the study medications are related to the heart. Eligible participants must be obese (BMI: 30-45 kg/m2) men and women, have high blood pressure, and have no history of heart or kidney problems. The study involves wearing a blood pressure monitor for 24 hours, 24-hour inpatient visits at UAB Hospital, taking medications, and collecting blood and urine samples. Meals will be provided at no cost. Participants will be compensated $575 for completing the study visits. Please e-mail Haley at PRECISION-BPSTUDY@uabmc.edu or call us at 205-975-5825 if you are interested.

• You have had a stroke, a heart attack (myocardial infarction), or have poor circulation (peripheral
• arterial disease)
• You are 55 years of age or older
• You are living with obesity (BMI ≥ 30 kg/m2 )
• You can have type 2 diabetes and/or chronic kidney disease
• You are able to attend regular clinic visits and receive phone calls over
• a period of 3 years

Help us find out by joining our study. The University of Alabama at Birmingham, Department of Nutrition Sciences, is conducting an exciting research study, in collaboration with Pennington Biomedical Research Center, to investigate whether intermittent fasting or calorie restriction (i.e., losing weight) can improve health and slow the aging process.

If you are randomly selected to do calorie restriction, you may lose weight by eating less. If you are randomly selected to do intermittent fasting, you will fast for 16 hours per day and eat dinner by 6 pm about 6 days per week (1 break day per week). We want you to be successful: the study provides intensive coaching and support to help you successfully lose weight or practice intermittent fasting.

To qualify, you should:

Be 25-45 years old
Have a BMI between 22-30 Calculate your BMI here
Be healthy
Not currently taking any medications or supplements for chronic conditions
Not smoke, vape, or use tobacco products currently or within the last 6 months
Not currently participate in a regular program of heavy physical activity (e.g., jogging, running, or riding fast on a bicycle for 30 minutes or more per day)
The study involves collecting a medical history, body fat and bone scans, blood draws, urine collection, questionnaires, and other simple tests. Participation in the study will last approximately 7 months. Compensation of up to $1,500 is offered for the completion of this study. If you are interested in participating and think you may be eligible, please click the button below to screen online, call 205-934-1457, or email dial@uab.edu.

We are looking for individuals with spinal cord injury to participate in a home based exercise program for improving cardiometabolic health outcomes, such as body weight, blood sugar, cholesterol, and cardiovascular fitness. To qualify you must have a confirmed diagnosis of SCI at the cervical or thoracic level (C7-T12, classified as A, B, C, or D on the AIS scale), be at least 3 years post-injury, aged 19-65 years old. Participants will exercise for 16-weeks from home using an arm crank cycle ergometer and will receive $300 for completing the study. For more information, and to see if you might be eligible to join, please contact (205) 996-4114 or email at grdnfs@uab.edu

Minimum Eligibility Requirements: • You are 18- to 35-years-old. • You are currently wearing glasses/contact lenses. • You know how to use soft contact lenses. • You have had an eye exam within the last 2 years This study includes four to six visits, which will happen over ten weeks. If eligible, you will be compensated $20 to $40/visit with a maximum of $140 for your participation in the study. If interested, please contact Keyur Savla at 205-212-0355 or ksavla@uab.edu for additional information.

You may be eligible to participate in a research study about the effects of Sacubitril/Valsartan or Valsartan on your body’s 24-hour rhythm of a hormone in your blood called natriuretic peptides. This hormone and the study medications are related to the heart. Eligible participants must be obese (BMI: 30-45 kg/m2) men and women and have no history of diabetes, heart problems, or kidney problems. The study involves consuming prepared meals, wearing a blood pressure monitor for 24-hours, a 24-hour inpatient stay, and collecting blood and urine samples. The meals will be provided at no cost. Participants will be compensated $560 for completing the study visits. Please e-mail Nehal at PRECISION-BPSTUDY@uabmc.edu if you are interested.

Overweight/Obese adult volunteers needed for study If you are between the ages of 18 -89 yrs and have a body mass index > 30 kg/m2 you may be eligible to participate in a study exploring the reason why individuals who have high BMI have an increased risk of forming calcium oxalate kidney stones. Participation involves eating study-provided meals for 4 days, providing urine and blood samples. Study meals are provided free of charge and additional compensation up to $140 is offered. For more information call 205-934-5712 or email kidneystone@uabmc.edu or kidneystoneresearch@uabmc.edu

Adults with Type 2 Diabetes needed for a study If you are between the ages of 18 -89 yrs and have type 2 diabetes you may be eligible to participate in a study exploring the reason why individuals who have diabetes have an increased risk of forming calcium oxalate kidney stones. Individuals who are obese, overweight, or normal weight are all welcome to the study. Participation involves eating study-provided meals for 4 days, providing urine and blood samples. Study meals are provided free of charge and additional compensation up to $140 is offered. For more information, call 205-934-5712 or email kidneystone@uabmc.edu or kidneystoneresearch@uabmc.edu.

Do you experience urine leakage with a strong and sudden urge and you leak before reaching the toilet? You may be eligible to participate in this important study if you are female and 21 years of age or older, if you are experiencing urine leakage with the feeling of urgency, coughing, sneezing, or laughing. For more information, contact our research team at 205-934-5498. Compensation is provided.

Do you experience accidental bowel leakage? You may qualify for a bowel leakage research study if you are female, 18 years or older, and have had accidental bowel leakage for at least 6 months. For more information contact 205-934-5498. Compensation is provided.

You may be eligible to participate in the UAB’s Cardiovascular Research Biobank (CARBON), a repository of biological samples that will be used for future research about heart disease, diabetes, genomics, and more. Participants must be over the age of 18. The study will require one brief visit to UAB and collection of blood samples. Participants will be compensated. Please contact Nehal Vekariya at carbonstudy@uabmc.edu or 205-934-7173 if you are interested.

Healthy Volunteers Needed If you are: • 18-50 years of age • Can read and write in English • Are generally healthy • And have no history of mental illness or psychiatric disorders

For more information and to determine eligibility, please call UAB Office of Psychiatric Research at (205) 934-8203. **Compensation is provided**

The UAB Epilepsy Center is looking for participants aged 15 and older for a brain imaging study. Eligible individuals will have psychogenic non-epileptic seizures (PNES) without co-morbid epilepsy. The study involves one visit at UAB Highlands Hospital and will last up to 2.5 hours. Participants will undergo a brain MRI, complete questionnaires, and provide a small amount of blood. You will be compensated $100 for completing the visit. If interested, please contact Dr. Christina Mueller at (205) 671-4355 or cm1@uab.edu.

Do you have a loved one with agitation associated with Alzheimer’s dementia? Is their agitation becoming overwhelming? Examples of some easily identifiable agitated behaviors are: restlessness, screaming, shouting, throwing things, resistiveness, constant unwarranted requests for attention or help, pacing/aimless wandering, kicking, hitting others or self, pushing people, hurting self or others, tearing things or destroying property. In this study, researchers want to find out if an investigational drug called AVP-786 is safe and effective (useful) in managing agitation in adults with Alzheimer’s dementia, when compared to a placebo. If you are a caregiver for a person with Alzheimer’s disease, please call (205) 996-5987 or email lalexander@uabmc.edu for more information.

The RECOVER study will investigate the use of Vagus Nerve Stimulation (VNS) Therapy in up to 1,000 people across the United States. To join the RECOVER study you must be 18 years or older and: currently depressed, have bi-polar depression that has lasted for at least two years or recurred several times, and have tried at least four types of antidepressant treatments and not found them helpful. Please leave a voice message at (205) 975-0068 or email candacegreen@uabmc.edu for more information.

We are looking for adults with type 2 diabetes for an exciting research study to see whether intermittent fasting and/or using light therapy can improve your blood sugar, improve your overall health, and reset your body clock. Participants will either eat early in the day, graze throughout the day, and/or use a special light therapy box or glasses. You may be eligible if you have type 2 diabetes, are 30-80 years old, are not taking insulin, and usually wake up between 5:00 and 9:00 am. The main part of the study lasts 16 weeks and involves two overnight tests in our clinic (which can be done on weekends, if preferred). Participants will receive $2400 for completing the study.

If you are interested, please follow the link http://bit.ly/clocksstudy to apply for the CLOCKS study. Or for more information, please contact our research team for more information at CLOCKSSTUDY@uab.edu or 205-484-7329 or 205-484-5633.

We are looking for adults for an exciting research study to see whether meal timing can improve your blood sugar, blood pressure, and your overall health. Participants will be randomized to follow an eating schedule for 8 weeks. You may be eligible if you are 30-70 years old, BMI between 30-60 kg/m2, are not taking diabetes medication, and wake up between 5:00 and 8:00 am regularly. Adults with prediabetes, blood sugar issues, or a family history of diabetes are encouraged to apply. This study involves two overnight tests plus eating only food that we provide you. Participants will receive $1200 for completing the study and 8 weeks of meals, valued at a total of $2400. If you are interested, please visit https://bit.ly/mealtimingstudy to apply for the study. Or for more information, please contact one of our research coordinators at mealtiming@uab.edu or 205-580-7692.