Research & Innovation

Women who have never smoked have smaller lung airways than men do, leading to higher risk for COPD.

The first known U.S. study evaluates the mental health of practicing dentists and dental hygienists during the COVID-19 pandemic.

X-ray crystallography revealed the structure of the HIV-1 matrix protein at 2.1 angstroms resolution, advancing understanding of key mechanisms of viral assembly.

Surprisingly, several competing models for this clathrin-mediated endocytosis all appear to function in two cell lines tested.

The investigators will look at diet’s impact on mobility, physical and cognitive function, as well as on pain, fatigue, sleep, mood and anxiety, in people with multiple sclerosis

This therapy, using sustained release of nitric oxide, may be a novel, efficient and safe way to prevent and treat multiple metabolic diseases.

The UAB Cardiogenomics Clinic provides genetic testing and counseling for a gene variant associated with a risk of heart failure and death.

COVID-related acute kidney injury peaked in 10- to 15-year-olds and 70- to 75-year-olds, suggesting age is not the sole determinant in severity of illness from COVID-19.

The monoclonal antibody cocktail is deliverable via a nasal dose, and it is also effective against SARS, MERS and several coronavirus cold viruses. The antibodies are engineered for long-acting effectiveness, potentially lasting a year or more when used in humans.

The fields of neuroengineering and brain-computer interfaces could have a tremendous impact on a number of neurologic conditions, such as stroke, neurodegenerative disorders, Parkinson’s disease, dementia and other brain diseases.

Traditional markers of cardiometabolic health may be lower in Black individuals, but the development of diabetes is more common in those with African ancestry.

Benefits of the blood pressure medication verapamil include delayed disease progression, lowered insulin requirements and preservation of some beta cell function.

Student-led study shows that those with autism spectrum disorder present difficulties in time estimation abilities while driving.

UAB physicians are working on the next steps to begin compassionate or emergency use of the pig kidneys in living humans. Two major approvals will be required.

In response to a viral infection, intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling, leading to different fates for two subsets of those cells — the one producing IL-2 and the one not producing IL-2.

Consortium led by UAB researchers in the UAB Heersink School of Medicine and School of Public Health received additional funding to further study chronic hypertension and preeclampsia epigenetics participants enrolled in the CHAP trial.

Death or severe brain bleeding in the first week after birth dropped from 27.4 percent to 15 percent after introduction of a bundle of evidence-based, potentially better practices for preterm infants. Median weight of the 820 infants studied was 1 pound, 10 ounces.

The findings represent the first study to examine whether metabolic adaptation, at the level of Resting Metabolic Rate (RMR), is associated with time to reach weight-loss goals.

Early research internships allow students to discover careers of interest they may not otherwise experience, providing an effective way to set them up for success, study suggests.

A new study confirms that G207, a genetically engineered virus developed at UAB, may be a beneficial therapy for brain tumors.

The human preclinical model at UAB provides important knowledge before a Phase I clinical trial can begin for living human recipients. Decades of work by researchers across the world preceded UAB’s first clinical-grade pig kidney xenotransplant.

A detailed mechanistic study unravels how the bacterial endotoxin LPS prevents or promotes allergic disease.

UAB researcher explains why retailers prefer customers to keep purchased items instead of returning.

Although unproven, this novel sickle cell therapy serves as a potential cure. More measures need to be taken to determine long-term function and organ improvement.

Research in animal models shows better formation of the fistulas, which are a lifeline for kidney failure patients as the connection site to dialysis machines.

After years of researching the SON gene, Erin Eun-Young Ahn, Ph.D., may have found the cause behind an extremely rare disease.

Recent studies have shown that formal exercise training can help boost memory, and memory deficit is relatively common in people with epilepsy.

Basic and translational research in this field aims to repair heart injury and prevent the heart failure that often follows a heart attack.

Bacteria use molecular machines to move proteins, including toxins, across cell membranes. M. tuberculosis, which kills more than 1 million people a year, uses the ESX-4 type VII secretion system to transports its potent exotoxin.

The study concluded that participants were hesitant to receive the COVID-19 vaccine due to mistrust, fear and lack of information.