Research & Innovation

Cong’s research indicates the increased vulnerability of older adults to climate change impacts while also highlighting their resilience capacity in the face of disasters, offering valuable insights for policy development and disaster preparedness.

Analysis of a survey of 18,041 people in rural KwaZulu-Natal revealed a discrepancy between the ability of the South African health system to respond to the health needs of people with communicable diseases and the health needs of people with non-communicable diseases.

The Blazer Bridge Fund is intended to identify and assist in the development of promising ideas, discoveries, innovations and/or technologies from UAB faculty and staff that have commercial potential.

UAB researchers conducted a study in end-stage heart failure patients with cardiogenic shock that revealed that B-type natriuretic peptide levels were elevated in end-stage heart failure but did not predict clinical outcomes.

Lung-resident memory B cells produced during influenza are long-living immune cells that migrate to the lungs from draining lymph nodes and lie in wait as early responders that can quickly react to future infections. They are key sentinels against subsequent viral variants.

The modified mRNA — delivered after experimental heart attacks — transiently allows heart muscle cells to proliferate, leading to reduced infarct size and improved heart performance compared to untreated animals.

While preventive treatment with vigabatrin delayed the onset and prevalence of infantile spasms in TSC infants, it had no impact on focal seizures, drug-resistant epilepsy, or improvement of cognitive and behavioral scores at 24 months.

The study’s findings provide valuable insights into the role of diet composition in Type 2 diabetes management.

These results add an additional, mechanistic aspect to further explain how the decades-old blood pressure medication verapamil can preserve beta cell function in Type 1 diabetes patients by affecting the hormone insulin-like growth factor 1.

The new technology will allow for non-invasive assessments for dry eye disease and inform the development of new treatments.

Periodontal disease is one of the leading causes of tooth loss in adults and may be a risk factor in the development of Alzheimer’s disease.

In a mouse model, border-associated macrophages, not microglia, were essential for the neuroinflammation that precedes neurodegradation. Targeting this subset could be a disease-modifying therapy in neurodegenerative disease.

UAB is one of the seven institutions receiving multimillion renewal funding to advance its Cyber Corps program. The grant will support an integrated curriculum for training master’s students in both cybersecurity and artificial intelligence.

Published results from two UAB studies found the duration of intermittent hypoxemia events and the presence and persistence of a patent ductus arteriosus after birth are two novel risk factors of BPD-PH in preterm infants.

New research reveals how influencers’ words impact engagement in affiliate marketing on social media
The UAB study revealed that specific linguistic styles within influencer posts can enhance or diminish engagement with the content.

Earlier research suggests that the use of low-dose atropine drops plays a role in slowing the progression of myopia in children. However, new research co-led by experts in the UAB School of Optometry shows that may not be the case.

Because hypertension and uncontrolled blood pressure are major risk factors for heart disease and stroke, achieving equity in heart and brain health in the United States cannot be reached without paying attention to social determinants of health, a study shows.

These nanowires, which can transport electrons to help a microbe make energy, were first described in a Geobacter bacteria; but now nanowires appear to be widespread in both bacteria and archaea prokaryotes.

Chronic obstructive pulmonary disease patients with type 2 inflammation saw rapid and sustained improvements in their disease after treatment with the monoclonal antibody dupilumab.

UAB researchers conducted a study including approximately 20,000 left ventricular assist device recipients and found that women had worse clinical outcomes compared with men across social and clinical subgroups of interest.

Results from the Chronic Hypertension and Pregnancy trial found treating preexisting mild chronic hypertension in pregnant women is safe from both the mom and baby. Results published in April 2022 have since led to changes in national guidelines.

New study indicates that StreetBit has the potential to save millions of dollars annually and reduce pedestrian injuries by implementing such programs on a larger scale.

Knowledge of this previously unrecognized mechanism may aid therapy for patients with interleukin-6 signaling mutations and hyper-IgE Syndrome, or HIES.

Uncovering a pathophysiological mechanism that initiates, transitions and sustains neuropathic pain holds promise for treating neuropathic pain.

Description of this mechanism offers a promising therapeutic target to limit lung injury and death. Lower respiratory tract infections, including bacterial pneumonia, are the fourth-leading cause of death worldwide, with 120 million to 156 million cases and 1.4 million deaths a year.

The drug appears to help strengthen pathways in the brain, improving the ability of neurons to communicate with each other.

Advanced warning of an elevated risk for seizures could help patients take protective measures to minimize the effects, or possibly even stop the seizure before it begins.

The study found that using a vaginal swab was more accurate than using urine for three types of sexually transmitted infections.

These effector memory B cells appear poised for a rapid serum antibody response upon secondary challenge one year later, and evidence shows that the cells in this subset differ from all previously described memory B cell subsets.

The trial will evaluate the effects of low doses of psilocybin on combating demoralization in broader populations.