Preclinical Detection of Sepsis Early in Hospitalized Patients Following Surgery, Injury or Severe Illness (Pre-SEPSIS Trial)

PI: Jan Jansen, M.D.
NCT#: 04189549

This program fosters research and instruction in the areas of trauma and hemorrhage to translate the experimental studies to the bedside using novel treatment modalities so that complications and mortality rates in such trauma patients can be decreased.

Along with the Center for Phase I Studies, the pharmacokinetic and pharmacodynamic studies have been contracted to a GLP facility to obtain safety and toxicity information for filing an IND application and obtaining approval from the FDA for conducting the Phase I studies of EE-3-SO₄. More specifically, the contract titled “Surviving Blood Loss: First In Human Studies To Assess Safety And Physiological Effects Of Synthetic Ethinyl Estradiol-3-Sulfate (EE-3-SO₄) In Healthy Subjects Both Euvolemic And Following 10-20% Inatrogenic Blood Loss” has been awarded since September 2015 to the tune of $10 million to complete the preclinical studies so that Phase I studies of EE-3-SO₄ can then be performed.

The Surgical Education Research Program studies the process by which we train future surgeons and surgical leaders. Our focus areas include surgical simulation, conflict management, robotic surgical curriculum, and surgery work hours as well as other educational interests. 

Faculty

• Corey, Britney, M.D.
• Fazendin, Jessica, M.D.
• Hendershot, Kimberly M., M.D.
• Lindeman, Brenessa, M.D., MEHP
• Pearce, Benjamin J., M.D.
• Porterfield, John R., M.D.
• Rogers, David A., M.D.
• Stahl, Richard D., M.D.
• Sutzko, Danielle, M.D., M.S.
• Vardas, Panayotis, M.D.
• Wei, Benjamin, M.D.

This basic science and translational research program is focused on elucidating the cause-and-effect mechanisms of endotheliopathy that drive organ dysfunction and coagulation abnormalities in the setting of traumatic injury and hemorrhagic shock. In combination with clinical studies and animal models of injury and inflammation, we utilize custom-designed bioengineered cell culture systems to study the impact of resuscitation strategies on glycocalyx degradation and glycocalyx structural modifications that dictate mechanisms of vascular inflammation, endothelial hyperpermeability, aberrant coagulation and impaired vasoreactivity. Our research efforts are aimed at the identification of therapeutic strategies to protect, restore or modify the endothelial glycocalyx to mitigate endotheliopathy and improve clinical outcomes for trauma patients.

• Advarra IRB - Non-Invasive Monitoring of Traumatic Brain Injury Progression Using The Infrascanner 1 (MOBI-1)
• Non-Invasive Monitoring of Traumatic Brain Injury Progression Using the Infrascanner (MOBI)
• Redesigning a trauma service to boost efficiency and outcomes

Crash Injury Research and Engineering Network (CIREN)

Prospective Evaluation of VR as an Educational Tool - Medical Simulation Training for SOST Advanced Resuscitative Care

• Current Practice Patterns in Antibiotic Duration in Necrotizing Soft Tissue Infection: A Surgical Infection Society Multicenter Study
• Management of Acute Appendicitis and Cholecystitis During the COVID-19 Pandemic: An EAST Multicenter Contemporaneous Cohort Study
• Over-transfusion with Blood for Suspected Hemorrhagic Shock Is Not Associated with Worse Clinical Outcomes
• University of Wisconsin-Madison IRB - A Randomized Clinical Trial of Scenario Planning for Older Adults with Serious Injury (Improving Communication in the ICU)

• Direct versus Indirect Transport of Injured Patients to Definitive Trauma Center Care
• Healthcare disparities in the receipt of guideline-concordant blood product resuscitation among patients in hemorrhagic shock following injury
• Mitigating Injury Disparities with Evidence Based Trauma Systems Planning
• Perceived Barriers Regarding the Use of Telemedicine to Improve Trauma Triage in Alabama
• Regional Blood Product Availability for Trauma Care in Alabama
• UPitt IRB - Type O Whole blood and assessment of AGE during prehospital Resuscitation (TOWAR) Trial
• Using the Agency for Healthcare Research and Quality (AHRQ) Healthcare Cost and Utilization Project (HCUP) nationwide databases to Study Epidemiology, Referral Patterns, Patient Injury and Hospital Factors, Geographic Factors, Quality of Care, Trauma Systems and Discharge Destinations Associated with Trauma Health Outcomes

• Chest Tube Education
• Seasonal and Geographic Variation in Mechanism of Trauma
• UAB Surgery Boot Camp: An Intern Prep Course for Students Pursuing a Surgical Residency

• A Review of Pain in Trauma Patients
• A Review of Sodium and Chloride Administration in Trauma Patients
• A Study of Healthcare Providers' Perceptions on the Use of CPR in Traumatic Cardiac Arrest
• A Survey of Military General Surgery Resident Attitudes Towards Their Training and Development of a Military Unique Curriculum
• Across the pond: Why are junior doctors seeking training abroad?
• Advarra IRB - SAFETY: Stabilization points to third hospital line Assessment oF Effectiveness of Infrascanner Model 2500 for diagnostic/screening of Traumatic Brain InjurY in Ukraine An Evaluation of Intraoperative Trauma Resuscitation Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA): A Prospective Observational Study of the Endovascular Skills in Trauma and Resuscitative Surgery (ESTARS) Working Group Characterizing the Accessibility of Trauma Systems Developing a Military Unique Curriculum for General Surgery Residents A Delphi Survey Effects of Pre-hospital Blood verses Crystalloid Administration on Arrival Body Temperature and Associated Outcomes in Trauma Patients EFIC Trial PI/RC Satisfaction with CC/PD Process Survey Expert Belief Elicitation for the “Trauma Resuscitation with Group O Whole Blood vs Products” (TROOP) Trial
• Injury Recidivism
• Interfacility Transfers of Trauma Patients: An Analysis of the Alabama Trauma System
• Perceptions of Hospital-Based Violence Intervention Programs
• Redesigning a trauma service to boost efficiency and outcomes
• REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam
• Transfusion Stewardship through Small Volume Pre-Packaged Blood Products
• Trauma Department Admissions and Length of Stay
• Understanding the Impact of the Closure of Rural Hospitals on the Access to Acute Care Surgery Using Global Information Systems
• Using Publicly Available Flight Data to Analyze Health Disparities in Aeromedical Retrieval