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You may be eligible to participate in a research study looking at the effects of sacubitril/valsartan on how your body handles sugar. This medication is related to blood pressure and is safe to take with or without hypertension. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart disease or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated $675 for completing all the visits. To participate, please contact Tiffany at 205-934-0534 or email us at nauticalstudy@uabmc.edu.

We are looking for volunteers to participate in a clinical study to advance lupus treatment.

If you are interested in seeing if you may qualify for an ongoing clinical study, please contact Christina Ndolo at cmndolo@uabmc.edu.

TRANSCEND-T2D-2 is a clinical research study for people with type 2 diabetes. This study will test if an investigational medicine (the medicine being studied) can help with blood glucose (sugar) and weight management compared with an existing treatment for type 2 diabetes. You may be able to join the research study if you are aged 18 years or older, have type 2 diabetes, have been taking 1500mg or more of metformin each day for at least 3 months (with or without SGLT2i), have a BMI of 25 or more, have HbA1c levels of 7.0% to 10.5%. For more information, please contact Tracie Thomas, RN, at 205-996-4015 or email tthoma@uab.edu

Eligible participants must be healthy adults (BMI less than 45 kg/m2) and have no history of diabetes, heart problems, or kidney problems. The study involves consuming prepared meals, performing exercise on a treadmill, undergoing a glucose test, and collecting blood, urine samples, and collection of genetic information. Participants will be compensated $300 for completing all the visits and meals will be provided at no cost. Please e-mail us at genesis@uabmc.edu or call us at (205) 975-3956 if you are interested.

About the Clinical Trial:

The purpose of this NIH funded trial is to examine the effects of three different diabetes treatments to determine if they improve night-time blood sugars.

This Trial Involves:

• A screening visit that includes a blood draw, urine test and physical exam
• Treatment with Metformin, Insulin Glargine (long-acting insulin) or the experimental drug Dorzagliatin which is FDA-approved for research, for up to 8 weeks
• 2-4 inpatient visits/ including two overnight stays at the Clinical Research Unit at 15th floor of Jefferson Tower.

All visits to be completed within a three-month period. Study-related tests and procedures are provided free of charge. Participants will be compensated up to $2,500 for study completion. All Participants must be Diagnosed with type 2 DM and Not on any type of insulin therapy.

Please contact Kathryn Hollifield-Laumer at khollifield@uabmc.edu or co-investigators Chanel Mason at 205-934-1921 or cnmason@uabmc.edu, or Alaaeldin Hodhod at ahodhod@uabmc.edu.

Join us at the Alabama Vaccine Research Clinic at UAB! We are looking for volunteers to join a Phase 1 clinical trial to test the safety and immune response of a new HIV vaccine. The study is for adults who are HIV-negative, in good health, and aged 18 to 55. Procedures will include blood draws and injections of the study vaccine, as well as the collection of white blood cells through a procedure called leukapheresis. Participants will be compensated for their time in this study. The study vaccine will not give you HIV. If you are interested, please call 205-934-6777 or email avrc@uabmc.edu. You can also fill out our contact form at https://sites.uab.edu/avrc/contact-us/.

Participants Needed. We are recruiting individuals who have experienced a stroke and are able to walk with minimal restriction and also age similar control participants that have NOT experienced a stroke between the ages of 18-89 for a research study on walking. The focus of this study is to understand how to optimize the delivery of a combined strength and aerobic training regimen to individuals with post stroke hemiparesis and reduce overuse and inefficiencies associated with the unaffected leg while walking. If you qualify, your participation in the study will span a single study visit, with a total time commitment of 3 hours. You will be compensated for your time. Please e-mail Christopher Hurt at cphurt@uab.edu or contact him by phone at 205-934-8517 if you are interested.

Study Information:

• Are you 18-60 years of age living with HIV, and want to be a part of a vaccine study?
• Is your viral load suppressed/undetectable?
• Are you able to receive a vaccine?
• Are you generally healthy?
• Are you willing to temporarily stop taking antiretrovirals?

You may qualify for a study looking at testing an experimental HIV vaccine with an experimental adjuvant to see how the immune responses change among participants who do an antiretroviral analytical treatment interruption (ATI) compared to those who do not. Compensation at each study visit will be provided for time and travel. Transportation services are also available upon request. If interested, please email sspaulding@uabmc.edu.

You may be eligible to participate in a research study looking at the effects of sacubitril/valsartan on how your body handles sugar. This medication is related to blood pressure and is safe to take with or without hypertension. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart disease or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated $675 for completing all the visits. To participate, please contact Tiffany at 205-934-0534 or email us at nauticalstudy@uabmc.edu.

Eligible participants must be healthy adults (BMI less than 45 kg/m2) and have no history of diabetes, heart problems, or kidney problems. The study involves consuming prepared meals, performing exercise on a treadmill, undergoing a glucose test, and collecting blood, urine samples, and collection of genetic information. Participants will be compensated $300 for completing all the visits and meals will be provided at no cost. Please e-mail us at genesis@uabmc.edu or call us at (205) 975-3956 if you are interested.

You may be eligible to participate in a research study looking at the effects of sacubitril/valsartan on how your body handles sugar. This medication is related to blood pressure and is safe to take with or without hypertension. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart disease or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated $675 for completing all the visits. To participate, please contact Tiffany at 205-934-0534 or email us at nauticalstudy@uabmc.edu.

Eligible participants must be healthy adults (BMI less than 45 kg/m2) and have no history of diabetes, heart problems, or kidney problems. The study involves consuming prepared meals, performing exercise on a treadmill, undergoing a glucose test, and collecting blood, urine samples, and collection of genetic information. Participants will be compensated $300 for completing all the visits and meals will be provided at no cost. Please e-mail us at genesis@uabmc.edu or call us at (205) 975-3956 if you are interested.

University of Alabama at Birmingham is seeking cigarette smokers who would like to quit smoking for participation in a scientific research study. The research study involves free counseling and treatment provided in a comfortable, supportive setting. The study may involve ingestion of psilocybin, a psychoactive substance found in psychedelic mushrooms that have been used as a sacrament in various cultures. Some research studies have suggested that psychedelics, when administered under interpersonally supportive and well-prepared conditions, may be effective in helping people overcome addictions.

Questionnaires, interviews, and biological measures of smoking will be used to assess the treatment's effects on mood and smoking. Participants will be compensated $50 per session. If you would like to discuss the possibility of volunteering, please call 205-996-1198, or go to www.quitsmokingbaltimore.org for more information about the study and to complete the online study prescreener for the UAB site. Confidentiality will be maintained for all applicants and participants.

Volunteers must be 21 years of age or older, and must live within travel distance of the study site in Birmingham.

There is an ongoing psychedelic clinical research study evaluating the safety and efficacy of an intranasal study drug for patients with treatment resistant depression.

To qualify patients need to be 18-75 years of age, failed to respond to an adequate dose & duration of at least 2 medicines for depression. If currently taking antidepressants, willing and able to discontinue.

If eligible, study participants will be expected to abstain from illicit drugs for the duration of the trial & attend all study visits & follow instructions from the study doctor. Study examinations will be at no cost to you.

For more information please contact 205-996-1198 or spremani@uab.edu

Eligible participants must be healthy adults (BMI less than 45 kg/m2) and have no history of diabetes, heart problems, or kidney problems. The study involves consuming prepared meals, performing exercise on a treadmill, undergoing a glucose test, and collecting blood, urine samples, and collection of genetic information. Participants will be compensated $300 for completing all the visits and meals will be provided at no cost. Please e-mail us at, genesis@uabmc.edu or call us at (205) 975-3956 if you are interested.

You may be eligible to participate in a research study looking at the effects of sacubitril/valsartan on how your body handles sugar. This medication is related to blood pressure and is safe to take with or without hypertension. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart disease or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated $675 for completing all the visits. To participate, please contact Tiffany at 205-934-0534 or email us at nauticalstudy@uabmc.edu.

We are looking for people with knee osteoarthritis to participate in a study to examine whether a diet intervention can reduce pain and improve quality of life. The commitment to this study will last approximately 7 weeks and include the following:

• Five (5) visits to UAB where you will fill out questionnaires, complete a DEXA scan, blood draw or Quantitative Sensory testing. These visits will last anywhere from 1-3 hrs.
• Six (6) weeks on a randomized diet where we will provide three (3) meals and two to three (2-3) snacks per day.

Participants must:

• Be currently suffering from pain related to knee osteoarthritis
• Be free from other serious health conditions (diabetes, cardiovascular disease, eating disorders, metabolic disease)

Participants will receive up to $250 for completing the study and meals will be provided. Please contact DIRECT at DIRECTPAIN1@gmail.com (205) 834-3628. Leave a short message with your name and number.

If you’re being treated for MDD and your current antidepressant medication(s) is not working, the SAVITRI Study might interest you. The SAVITRI Study is researching a potential MDD therapy to improve symptoms of depression, and you may be able to participate. This research study is now enrolling adults diagnosed with MDD. Those who qualify will receive the investigational medication (or placebo), study-specific medical exams, and study-specific laboratory tests at no cost. Participants in the SAVITRI Study must: be 18 to 65 years of age; have a clinical diagnosis of MDD; be currently on antidepressant medication(s); have had inadequate response to up to 5 oral antidepressant medications; and fulfill other eligibility criteria. For more information, please call (205) 996-5987 or email lalexander@uabmc.edu. Please mention SAVITRI in your message.

UAB researchers are looking for adults (ages 25-65) who are suffering from demoralization - feelings of hopelessness or meaninglessness - to participate in a research study evaluating a novel medication.

To see if you qualify call 205-379-7527.

Help us find out by joining our study at UAB by participating in the PRECISION-BP research study investigating the effects of Sacubitril/Valsartan or Valsartan on your body’s 24-hour rhythm of a hormone in your blood called natriuretic peptides. This hormone and the study medications are related to the heart. Eligible participants must be obese (BMI: 30-45 kg/m2) men and women, have high blood pressure, and have no history of heart or kidney problems. The study involves wearing a blood pressure monitor for 24 hours, 24-hour inpatient visits at UAB Hospital, taking medications, and collecting blood and urine samples. Meals will be provided at no cost. Participants will be compensated $575 for completing the study visits. Please e-mail Haley at PRECISION-BPSTUDY@uabmc.edu or call us at 205-975-5825 if you are interested.

You may be eligible to participate in a research study looking at the effects of sacubitril/valsartan on how your body handles sugar. This medication is related to blood pressure and is safe to take with or without hypertension. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart disease or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated $675 for completing all the visits. To participate, please contact Tiffany at 205-934-0534 or email us at nauticalstudy@uabmc.edu.

Help us find out by joining our study at UAB You may be eligible to participate in the PRECISION-BP research study investigating the effects of Sacubitril/Valsartan or Valsartan on your body’s 24-hour rhythm of a hormone in your blood called natriuretic peptides. This hormone and the study medications are related to the heart. Eligible participants must be obese (BMI: 30-45 kg/m2) men and women, have high blood pressure, and have no history of heart or kidney problems. The study involves wearing a blood pressure monitor for 24 hours, 24-hour inpatient visits at UAB hospital, taking medications, and collecting blood and urine samples. Meals will be provided at no cost. Participants will be compensated $575 for completing the study visits. Please e-mail Nehal at PRECISION-BPSTUDY@uabmc.edu or call us at 205-934-7173 if you are interested

If you’re being treated for MDD and your current antidepressant medication(s) is not working, the SAVITRI Study might interest you. The SAVITRI Study is researching a potential MDD therapy to improve symptoms of depression, and you may be able to participate. This research study is now enrolling adults diagnosed with MDD. Those who qualify will receive the investigational medication (or placebo), study-specific medical exams, and study-specific laboratory tests at no cost. Participants in the SAVITRI Study must: be 18 to 65 years of age; have a clinical diagnosis of MDD; be currently on antidepressant medication(s); have had inadequate response to up to 5 oral antidepressant medications; and fulfill other eligibility criteria. For more information, please call (205) 996-5987 or email lalexander@uabmc.edu. Please mention SAVITRI in your message.

Do you have a loved one with agitation associated with Alzheimer’s dementia? Is their agitation becoming overwhelming? Examples of some easily identifiable agitated behaviors are: restlessness, screaming, shouting, throwing things, resistiveness, constant unwarranted requests for attention or help, pacing/aimless wandering, kicking, hitting others or self, pushing people, hurting self or others, tearing things or destroying property. In this study, researchers want to find out if an investigational drug called AVP-786 is safe and effective (useful) in managing agitation in adults with Alzheimer’s dementia, when compared to a placebo. If you are a caregiver for a person with Alzheimer’s disease, please call (205) 996-5987 or email lalexander@uabmc.edu for more information.

You may be eligible to participate in a research study looking at the effects of sacubitril/valsartan on how your body handles sugar. This medication is related to blood pressure and is safe to take with or without hypertension. Eligible participants must be healthy men and women, African American, and have no history of diabetes, heart disease or kidney problems. The study involves performing some exercise, taking sacubitril/valsartan, and collecting blood samples. Participants will be compensated $675 for completing all the visits. To participate, please contact Haley at 205-975-5825 or email us at nauticalstudy@uabmc.edu.