Have you experienced... Feeling hopeless? Feeling sad or down? Feeling guilty? Increase or decrease in appetite? Loss of interest in activities? Inability to concentrate? Forgetfulness? Trouble sleeping or sleeping too much? Wishing you were dead? If you answered yes to some or all of these questions and you are: ages 19-65 and in good physical health, you may be eligible to participate in a research study for treatment of depression, involving a one time dose of ketamine. For more information, please call UAB Office of Psychiatric Research at 205-934-2484. Compensation is provided.