By Award Date
Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma, Department of Defense/National Trauma Institute, NTI-NCH-10-013, 08/16/2012-03/28/2014; PI - Jean Francois Pittet, M.D.: Co-Investigator – Jeffrey D. Kerby, M.D., Ph.D.
The study proposes to determine whether the administration of a low-cost and safe therapy, i.e., antioxidant vitamins C and E, given early after severe trauma would attenuate the post-traumatic coagulation derangements and significantly decrease lung infections in trauma patients.
Integrated Mixed Reality and Live Tissue-Based Medical Simulation Training Environment, U.S. Army Telemedicine and Advanced Technology Research Center (TATRC); W911NF-11-2-0084; 09/22/11-03/21/13; PI – Bharat Soni, Ph.D.; Co-PI – Jeffrey D. Kerby, M.D., Ph.D.
The focus of this project is on the development and application of contents for training military personnel by integrating information visualization and high fidelity computational simulations with virtual and mixed reality environments. It will establish the necessary infrastructure and processes to efficiently design and build virtual reality training environments for high priority medical training needs utilizing the extent of current and future technologies available to make the training environments as realistic as possible.
University of Missouri Columbia Combat Casualty Training Consortium (CCTC): Trauma Hemorrhage Control, U.S. Army/University of Missouri (Columbia), C00032991-3, 09/01/11-10/01/13, PI – Jeffrey D. Kerby, M.D., Ph.D.
This project addresses one of three Critical Research Areas under the University of Missouri (Columbia) award entitled “Combat Casualty Training Consortium (CCTC) for the study of militarily relevant trauma training seeking to validate and compare both live tissue and simulator based training methodologies.” The study strives to provide a comprehensive description, evaluation and assessment of the use of live tissue, simulation, and civilian trauma centers in training the critical research areas of trauma hemorrhage, trauma airway and emergency medical skills. This research proposes that medical simulation and live tissue training can be validly used in a verified and accredited way in military trauma and emergency medicine combat casualty care for these critical research areas.
Training Program for the Development and Maintenance of Surgical Skills for Field Operational Surgery for Air Force Unit Type Codes or Deployable Assemblages Using the Pig, DOD – Department of the Air Force, FA4417-11-P-R045, 04/01/11-03/31/16, PI – Jeffrey D. Kerby, M.D., Ph.D.
The purpose of this training program is to provide realistic experience in surgical procedures for Air Force medical readiness teams, designed to bring surgical capability to locations without that capability (i.e. forward combat areas, disaster areas, and aircraft or ships).
Prospective, Randomized Optimal Platelet and Plasma Ratios (PROPPR), NIH/University of Texas Health Science Center (Houston), 0008027G, 01/01/11-12/31/14, PI - Jeffrey D. Kerby, M.D.
As part of the Resuscitation Outcomes Consortium (ROC), centers will conduct a Phase III trial to compare 24-hour mortality in subjects receiving differing ratios of plasma and platelets relative to red blood cells (RBCs). UAB will be one of four Level I Adult Trauma Centers in the Vanguard Study and one of 12 such centers in the continuation stage.
Resuscitation Outcomes Consortium Registry, American Heart Association/University of Washington, 705341, 09/01/10-06/30/12, PI – Jeffrey D. Kerby, M.D., Ph.D.
A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study to Investigate the Efficacy and Safety of Progesterone Infusion in Patients with Severe Traumatic Brain Injury, BHR Pharma, LLC, BHR-100-301, 08/01/10-03/31/11, PI – Sherry M. Melton, M.D.
The University of Alabama at Birmingham (UAB) Crash Injury Research and Engineering Network (CIREN) Center, USDOT National Highway Traffic Safety Administration, DTNH22-10-H-00297, 06/01/2010-05/31/2015, PI – Donald A. Reiff, M.D.
CIREN is a multi-center research program involving a collaboration of clinicians and engineers in academia, industry and government pursuing in-depth studies of crashes, injuries and treatments. Its mission is to improve the prevention, treatment, and rehabilitation of motor vehicle crash injuries to reduce deaths, disabilities, and human and economic costs.
Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Alabama, NIH – National Heart, Lung, and Blood Institute, 5U01HL077881-08, 03/01/10-12/31/15, PI – Jeffrey D. Kerby, M.D., Ph.D.
The goal of this project is to assess pre-hospital resuscitation methods and their outcomes in a collaborative environment with pre-hospital personnel that include EMTs and Paramedics from participating agencies in the consortium’s Alabama region.
RBC Age and Potentiation of Transfusion - Related Pathology in Trauma Patients, NIH – National Heart, Lung, and Blood Institute, R01HL095468, 09/18/09-07/31/13; PI – Rakesh Patel, Ph.D.; Co-Investigators – Jeffrey D. Kerby, M.D., Ph.D.; Paul A. MacLennan, Ph.D.
The objective of this study is to provide significant insight concerning the mechanisms responsible for the clinically negative manifestations associated with transfusion of relatively older RBC units.
Training Program for the Development and Maintenance of Surgical Skills for Field Operational Surgery for Air Force Unit Type Codes or Deployable Assemblages Using the Pig, DOD – Department of the Air Force, FA4417-08-P-R033, 01/17/08-01/16/11, PI – Jeffrey D. Kerby, M.D., Ph.D.
The purpose of this training program is to provide realistic experience in surgical procedures for Air Force medical readiness teams, designed to bring surgical capability to locations without that capability (i.e. forward combat areas, disaster areas, and aircraft or ships).
Vascular and Inflammatory Responses During Resuscitation with New HBOC Products Following Hemorrhage: Evaluation in Small Animal Models, DOD – Department of the Navy, N00189-07-C-Z-108, 08/30/07-12/31/08, PI – Jeffrey D. Kerby, M.D., Ph.D.
Study of Resource Distribution Relative to Motor Vehicle Collisions (MVC’s) in Alabama, U.S. Department of Transportation/Federal Highway Administration, DTFH61-99-X-00039, 10/01/06-05/31/09, PI – Loring W. Rue, III, M.D.
This study evaluated the status of the Alabama EMS System and the characteristics of motor vehicle collisions that occur in the state.
Inflammatory Response Following Resuscitation with HBOC-201 after Hemorrhage: Evaluation in a Small Animal Model, DOD – Department of the Army/Biopure Corporation, DAMD17-02-1-0697, 10/01/06-02/28/07, PI – Jeffrey D. Kerby, M.D., Ph.D.
A Phase 2 Study of Recombinant Human Thrombin (rh Thrombin) Administered using a Spray Applicator in Subjects Undergoing Autologous Skin Grafting Following Burn of Traumatic Skin Injury, Zymogenetics, Inc., 499E02, 07/18/06-08/17/07, PI – James M. Cross, M.D.
Trauma Care System Research & Development, U.S. Department of Transportation/ Federal Transit Administration, AL-26-7261, 07/03/06-03/31/12, PI – Loring W. Rue, III, M.D.
This project sought to demonstrate how data resources, information flows, and the existence of a formalized trauma system might potentially be used to affect outcomes from a mass transit standpoint. More specifically, the CIS applied motor vehicle collision investigative techniques to a representative charter bus rollover accident in Springville, Alabama, first by studying trauma system response to the mass casualty incident (MCI), and then by using vehicle dynamics and occupant kinematics to determine anticipated injuries from such an event. While the first two general areas of investigation address an MCI from the standpoint of when it is happening and immediately thereafter, an additional year allowed the CIS to conduct a pre-event study of distracted driving behaviors for mass transit operators as well as private automobile operators.
Southeastern Resuscitation Research Center, NIH –National Heart, Lung, and Blood Institute, 5U01HL77881-05, 07/01/06-04/30/10, PI – Jeffrey D. Kerby, M.D., Ph.D.
Resuscitation Outcomes Consortium (ROC) Protocols, NIH/University of Washington, 297611, 07/01/06-02/28/10, PI – Jeffrey D. Kerby, M.D., Ph.D.
Enhanced Survival Following Trauma Hemorrhage and Extended Period of Hypotension Using Hormonal and Metabolic Support; DOD Defense Advanced Research Projects Agency (DARPA); W911NF-06-1-0219; 07/01/06-09/30/09; PI - Irshad H. Chaudry, Ph.D.; Co-PI – Loring W. Rue, III, M.D.
Develop novel supportive regimens that will enable war fighters to stabilize injured comrades experiencing life-threatening blood loss for extended periods of time, and delay the onset of irreversible circulatory shock, thereby permitting increased time for evacuation, triage, and initiation of supportive therapies.
A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Effect of Recombinant Human Erythropoietin (epoetin alfa; PROCRIT) on Functional Outcomes in Anemic, Critically Ill, Trauma Subjects, Ortho Biotech Products, LP, PR04-15-001, 02/22/06-02/21/09, PI – Sherry M. Melton, M.D.
Resuscitation Outcomes Consortium Registry, American Heart Association/University of Washington, 326034, 01/01/06-05/30/10, PI – Jeffrey D. Kerby, M.D., Ph.D.
Automated Crash Notification (ACN) System Integration, Alabama Department of Transportation in cooperation with the USDOT Federal Highway Administration, ITS-SP04(902), 09/29/04-01/15/07, PI – Loring W. Rue, III, M.D.
The major goal of this project was to study integration of advanced automatic crash notification (AACN) technology with an organized trauma system in order to more rapidly identify injurious motor vehicle collisions and expedite the provision of appropriate care.
A Study to Assess the Safety and Efficacy of Eibrin Sealant with 4TU/mL Thrombin (1<5 4113 VH S/D) to Adhere Tissues and Improve Wound Healing, Baxter Healthcare Corporation, 550201, 09/13/04-03/31/06, PI – James M. Cross, M.D.
Assessment of Neurologic Function in the Prehospital Setting: Comparison of Glasgow Coma Score and Motor Only Scores to Functional Outcome and Mortality, Brain Trauma Foundation and National Highway Traffic Safety Administration, DTNH22-98-G-05131, 03/01/04-02/28/05, PI – Jeffrey D. Kerby, M.D., Ph.D.
A Randomized Double-blind, placebo-controlled study to determine the Efficacy and Safety of Epoetin Alfa in Critically Ill Subjects, Johnson & Johnson Pharmaceutical Research & Development LLC, #EPO-ICU-002, 12/16/03-05/15/06, PI – Sherry M. Melton, M.D.
RESIST (Retrospective Evaluation of Severity of Illness and Shock in Trauma), Ortho-Biotech Products, L.P., #PR02-15-045. 04/15/03-04/14/04, PI – Sherry M. Melton, M.D.
Multicenter TBI Clinical Trials Network, NIH – National Institute of Child Health and Human Development, #U01 HD42687-01, 09/05/02-06/30/10; PI – Thomas A. Novack, Ph.D.; Co-PI – Sherry M. Melton, M.D.
University of Alabama at Birmingham “Traumatic Brain Injury” study designed to evaluate the relationship between acute care practice and rehabilitation strategies to the long-term functional outcome of TBI patients.
Automated Crash Notification (ACN) System Integration (Pilot), Alabama Department of Transportation in cooperation with the USDOT Federal Highway Administration, ITS-AL01(900), 03/18/02-03/17/05, PI – Loring W. Rue, III, M.D.
The major goal of this project was to study integration of automatic crash notification (ACN) technology with an organized trauma system in order to more rapidly identify injurious motor vehicle collisions and expedite the provision of appropriate care. The pilot phase included hardware acquisition, software development, telematics and PSAP coordination, and analysis of data flow.
Efficacy of rHuEPO in the Critically Ill Patient - A Randomized, Double-blind, Placebo- Controlled Trial, Ortho-Biotech, Inc., #PR98-15-014, 04/01/01-12/31/02, PI – Sherry M. Melton, M.D.
ATR Database Management, Alabama Department of Public Health, C1119108-2001-115, 03/01/01-09/30/01, PI – Loring W. Rue, III, M.D.; Co-PI – Gerald McGwin, Ph.D.
This contract provided support for a day-to-day database manager in the Center for Injury Sciences and contracted the Center to oversee the Alabama Trauma Registry (ATR).
Epidemiologic Research in Trauma [Patient Care Report (PCR) Database Management]; Alabama Department of Public Health; C00118081, C10119098, C20113078, C30117086; 11/01/00-10/31/05, PI – Loring W. Rue, III, M.D.; Co-PI – Gerald McGwin, Ph.D.
These contracts with ADPH provided for the electronic receipt, analysis and reporting of state Patient Care Report (PCR) data by UAB.
Injury Science Research, USDOT National Highway Safety Traffic Safety Administration, DTNH22-00-H-07337, 09/26/00-09/25/05, PI – Loring W. Rue, III, M.D.
This multidisciplinary effort involved the study of human surrogate response and injury under impact conditions associated with motor vehicle crashes.
An Open Label Study to Evaluate the Incidence of Wound Infection in Patients Requiring a Temporary Covering for Excised Burn Wounds, Advanced Tissue Sciences, Inc., TC-01-07-0597, 04/02/00-08/05/05, PI – James M. Cross, M.D.
UAB Traumatic Brain Injury Program, USDOT National Highway Traffic Safety Administration, DTNH22-99-G-05139, 07/16/99 – 09/30/02, PI – Loring W. Rue, III, M.D.
The focus of this project was to facilitate the implementation of component parts of the State of Alabama’s Statewide Traumatic Brain Injury (TBI) Plan, including the creation of an integrated statewide data registry for moderate to severe head injury and spinal cord injury cases.
The Study of Advanced Trauma Care, U.S. Department of Transportation/Federal Highway Administration, DTFH61-99-X-00039, 06/01/99-05/31/06, PI – Loring W. Rue, III, M.D.
The major goal of this project was to conduct research relative to expansion of the Birmingham Regional Trauma Plan into a truly comprehensive statewide trauma system. The objectives of the statewide system included provision of an integrated program of clinical care, clinical and basic scientific research, prevention, community outreach, and professional education.
Mercedes-Benz Crash Injury Research and Engineering Network (CIREN) Center at UAB, USDOT National Highway Traffic Safety Administration, sponsored by Mercedes-Benz, DTNH22-99-H-08642, 04/20/99-04/19/04, PI – Loring W. Rue, III, M.D.
As part of NHTSA’s CIREN Center program, the CIS worked with Mercedes-Benz to conduct research to improve motor vehicle and traffic safety, diagnose specific problems and implement standards and programs to address these problems, and evaluate their impact.
State of Alabama Comprehensive Trauma System, Alabama Department of Transportation in cooperation with the Federal Highway Administration, HPP-1602(525), 03/11/99-03/10/04, PI – Loring W. Rue, III, M.D.
This project conducted basic research relative to the development of a statewide trauma system that will streamline transportation of injured people throughout Alabama to the most appropriate trauma hospital setting. Supported projects include: Role of FGF-I in Initiating Bone Repair, J. Anthony Thompson, PhD (1999-2004); Role of FGF-I in Spinal Cord Regeneration, J. Anthony Thompson, PhD (1999-2004); and Relative Contribution of Oxidant Species in Hepatic Ischemia-Reperfusion Injury, Lee Ann MacMillan-Crow, PhD (1999-2004).
A Multicenter Phase III Study to Assess the Safety and Efficacy of Bactericidal/Permeability-Increasing Protein (RBPI21) in Patients with Hemorrhage Due to Trauma, XOMA (USA) LLC, BPTR335, 08/01/98-07/31/00, PI – Addison K. May, M.D., Sherry M. Melton, M.D.