Case History:
A young adult patient with a history of HIV presents with epigastric pain. On upper GI endoscopic exam, there are multiple erythematous mucosal nodules seen throughout the duodenum. A biopsy of a nodule was taken. H&E, ERG, and HHV-8 stains are shown.
Which of the following is most likely linked to this tumor?
A. Spindle cell hemangioma
B. Kaposi Sarcoma
C. Pseudomyogenic hemangioendothelioma
D. Angiosarcoma
Correct Answer: B. Kaposi Sarcoma
Case contributed by:
Oyedele Adeyi, M.D., FRCPC, C. Bruce Alexander Endowed Professor, Anatomic Pathology, Division Director, Anatomic Pathology, Gastrointestinal Section Head