A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of
Lebrikizumab/LY3650150 in Adult Participants with Chronic Rhinosinusitis with Nasal Polyps on Background Intranasal Corticosteroids
The purpose of this study is to evaluate the efficacy and safety of lebrikizumab in adult participants with chronic rhinosinusitis with nasal polyps treated with intranasal corticosteroids.
Principal Investigator: Do-Yeon Cho, MD
Phase II Open-Label Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Head and Neck Cancer During Surgical Procedures
The purpose of the study is to determine the efficacy of panitumumab-IRDye800 to identify cancer compared to surrounding normal tissue (tumor to background ratio/TBR ).
Principal Investigator: Anthony Morlandt, DDS, M.D.
Treating Obstructive Sleep Apnea using Targeted Hypoglossal Neurostimulation
The purpose of this study is to demonstrate the safety and effectiveness of the aura6000®️ System after 6 months of stimulation therapy when compared to a control group with no stimulation, when used in patients with moderate to severe obstructive sleep apnea.
Principal Investigator: Kirk Withrow, M.D.
A multicenter study to assess the safety and effectiveness of the Genio®️ dual-sided hypoglossal nerve stimulation system for the treatment of obstructive sleep apnea in adult subjects.
The aim of this study is to evaluate the safety and effectiveness of the Genio®️ System in moderate to severe obstructive sleep apnea (OSA) adult participants over a period of 12 months post-surgery.
Principal Investigator: Kirk Withrow, M.D.
Invacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (EDSPD Protocol)
The purpose of this study is to establish the novel endoscopically-directed sinus potential difference (EDSPD) assay as an endpoint for therapy of sinus disease. This assay provides a means to measure CI-secretion across the sinus epithelium in human subjects with chronic rhinosinusitis (CRS) and test the relationship between this data and endoscopic findings of inflammation.
Principal Investigator: Bradford Woodworth, M.D.