Jeff Hansen
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Overexpression of CCND2 increased growth and division of grafted heart muscle cells, resulting in better heart function and decreased size of dead tissue.
These results, seen in animal models, represent a potentially novel therapeutic target for the treatment of seizure disorders.
Low dietary potassium leads to calcified arteries and aortic stiffness, while increased dietary potassium alleviates those undesirable effects in a mouse model, suggesting dietary potassium may protect against heart disease and death from heart disease in humans.
Researchers study the mechanisms that prevent autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus or multiple sclerosis after an infection.
This knowledge can provide targets in the search for novel bone-loss therapeutics to treat osteoporosis.
A fatty acid-derived bioactive molecule called lipoxin improved heart function after a heart attack, as the lipoxin prompted early activation of the resolving phase of the immune response.
These new results, led by primary author Warner Huh, M.D., strengthen the promise that vaccination with Gardasil 9 can reduce 90 percent of cervical cancers.
Understanding the mechanisms that turn sets of genes on or off is a fundamental quest in biology, and one that has clinical importance in diseases like cancer, where gene control goes awry.
Researchers have discovered the mechanism of this control, with implications for developmental biology, the immune response and cancer dysregulation.