UAB Department of Urology Drs. Dean Assimos, Ross Holmes, John Knight and Kyle Wood, along with UAB Department of Nutrition Sciences Dr. Barbara Gower have been awarded a P20 exploratory grant to establish an interdisciplinary research center in benign urology. Funded through the NIDDK, the grant provides $200,000/year for two years toward research on the impact of obesity in endogenous oxalate synthesis. 

Over the last few years, UAB Urology has worked closely with UAB's Nutrition Obesity Research Center (NORC) and Dr. Gower. The complementary expertise has led to novel findings in obesity and kidney stone disease. A new center, COOKS (Center for Research on Obesity and Oxalate Kidney Stones), has been created through the P20.  

The prevalence of both kidney stones and obesity are increasing in the United States. The Southeast is considered the kidney stone belt, a region of the country where there is the highest prevalence of kidney stone formers. While the associations between obesity and kidney stone risk have been defined, the mechanisms behind this relationship is unknown.

Preliminary data supports a direct relationship between obesity and the amount of urinary oxalate excreted derived from endogenous oxalate production. Oxalate is a part of the most common type of kidney stone.

The goal of the P20 is to increase the understanding of the relationships between obesity and endogenous oxalate synthesis and hopefully serve as a platform to develop novel therapies for stone prevention.