Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a national research consortium designed to discover and perform preliminary characterization of the range of molecular transducers (the "molecular map") that underlie the effects of physical activity in humans. The program's goal is to study the molecular changes that occur during and after exercise and ultimately to advance the understanding of how physical activity improves and preserves health. The six-year program is the largest targeted NIH investment of funds into the mechanisms of how physical activity improves health and prevents disease.

The purpose of the study is to test the effects of 10 weeks of exercise on the number of blood vessels in the back of eyes and on memory and thinking function in individuals with hypertension between 55-75 years of age. This study will include three eligibility (2 baseline and 1 pre-intervention) visits, 40 exercise sessions over 10 weeks, and two follow-up visits that involve questionnaires, blood draws, fitness evaluations, memory and thinking assessments, and eye scans.